PRKAR1A antibody

Catalog No. ABIN317770

Product Details anti-PRKAR1A Antibody

Target: PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRKAR1A antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificity: PKR1 antibody detects endogenous levels of PKR1 protein.(region surrounding Phe58)

Purification: Affinity chromatography

Application Details

Application Notes: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PRKAR1A

Target: PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))

Alternative Name: PRKAR1A (PRKAR1A Products)

Synonyms: ACRDYS1 antibody, ADOHR antibody, CAR antibody, CNC antibody, CNC1 antibody, PKR1 antibody, PPNAD1 antibody, PRKAR1 antibody, TSE1 antibody, 1300018C22Rik antibody, RIalpha antibody, Tse-1 antibody, Tse1 antibody, RIIA antibody, prkar1a antibody, zgc:92515 antibody, im:7047729 antibody, cnc1 antibody, pkr1 antibody, ppnad1 antibody, prkar1 antibody, tse1 antibody, protein kinase cAMP-dependent type I regulatory subunit alpha antibody, protein kinase, cAMP dependent regulatory, type I, alpha antibody, protein kinase cAMP-dependent type 1 regulatory subunit alpha antibody, protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a antibody, cAMP-dependent protein kinase type I-alpha regulatory subunit pseudogene antibody, protein kinase cAMP-dependent type I regulatory subunit alpha S homeolog antibody, PRKAR1A antibody, Prkar1a antibody, prkar1aa antibody, LOC707275 antibody, prkar1a.S antibody

Background: The prokineticin receptors, PKR1 (GPR73a) and PKR2 (GPR73b), are G proteincoupled receptors responsible for mediating the signal transduction of both EG-VEGF and Prokineticin-2. PKR1 and PKR2 share 87 % sequence identity. PKR1 is predominantly expressed in the peripheral tissues and PKR2 is typically expressed in the CNS. Both receptors are found in the testis. Upon ligand binding, PKR1 and PKR2 associate with G protein and can promote intracellular calcium mobilization, stimulate phosphoinositide turnover and activate the MAPK pathway. These receptors play a role in a variety of physiological events such as intestinal contraction, ingestive behavior, spermatogenesis, angiogenesis, circadian rhythm, neuronal survival and hyperalgesia. PKR1 may promote cardiomyocyte survival. PKR2 is essential for the normal development of the olfactory bulb. Mutations in the gene encoding PKR2 may result in Kallmann syndrome type 3.Synonyms: CAR, CNC1, PKR1, PRKAR1, TSE1, Tissue-specific extinguisher 1, cAMP-dependent protein kinase type I-alpha regulatory subunit

Molecular Weight: approx. 45 kDa

Gene ID: 5573

NCBI Accession: NP_002725

UniProt: P10644

Pathways: Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma