TLR4 antibody
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- Target See all TLR4 Antibodies
- TLR4 (Toll-Like Receptor 4 (TLR4))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This TLR4 antibody is un-conjugated
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Application
- Flow Cytometry (FACS), ELISA
- Specificity
- Human Toll-like Receptor 4 (TLR4) The Toll-like receptor (TLR) family is comprised of Type I transmembrane proteins characterized by an extracellular leucine-rich domain and a cytoplasmic tail that contains a conserved region call the Toll/IL-1 (TIR) domain. First discovered in Drosophila, TLRs recognize specific molecular patterns that are present in microbial components and respond to these components in order eliminate or limit invading microbes. To date, ten mammalian homologs of TLRs have been described. TLR4 is involved in the recognition of lipopolysaccharide (LPS), an abundant glycolipid of Gram-negative bacteria. Through its association with MD-2 and CD14, TLR4 recognizes and initiates multiple intracellular signaling events such as the activation of NF-B leading to the ultimate synthesis and release of a number of proinflammatory mediators including interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α(TNF-α). TLR4 has also been associated in the recognition of and lipocheic acid (LTA), Hsp60 and Hsp70.1-10
- Characteristics
- Mouse Anti-Human TLR4-UNLB
- Purification
- Purified
- Clone
- 1E11
- Isotype
- IgG2a
- Top Product
- Discover our top product TLR4 Primary Antibody
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- Application Notes
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- Applications: Enzyme-Linked-Immunosorbent-Assay (ELISA) Flow Cytometry
- Working Dilutions: ELISA: Purified antibody 1:2000-1:4,000 Flow: Purified antibody ≤3 μg/106 cells
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- 0.1 mg purified immunoglobulin in 0.2 mL of borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added
- Preservative
- Without preservative
- Handling Advice
- Each reagent is stable for the period shown on the bottle label if stored as directed.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C
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- Target
- TLR4 (Toll-Like Receptor 4 (TLR4))
- Alternative Name
- TLR4 (TLR4 Products)
- Synonyms
- ARMD10 antibody, CD284 antibody, TLR-4 antibody, TOLL antibody, Lps antibody, Ly87 antibody, Ran/M1 antibody, Rasl2-8 antibody, toll like receptor 4 antibody, toll-like receptor 4 antibody, TLR4 antibody, Tlr4 antibody
- Background
- The Toll-like receptor (TLR) family is comprised of Type I transmembrane proteins characterized by an extracellular leucine-rich domain and a cytoplasmic tail that contains a conserved region call the Toll/IL-1 (TIR) domain. First discovered in Drosophila, TLRs recognize specific molecular patterns that are present in microbial components and respond to these components in order eliminate or limit invading microbes. To date, ten mammalian homologs of TLRs have been described. TLR4 is involved in the recognition of lipopolysaccharide (LPS), an abundant glycolipid of Gram-negative bacteria. Through its association with MD-2 and CD14, TLR4 recognizes and initiates multiple intracellular signaling events such as the activation of NF- κB leading to the ultimate synthesis and release of a number of proinflammatory mediators including interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor- α (TNF-α). TLR4 has also been associated in the recognition of and lipocheic acid (LTA), Hsp60 and Hsp70.
- Pathways
- TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins
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