ITPR2 antibody (AA 1152-1164)

Catalog No. ABIN461932

Product Details anti-ITPR2 Antibody

Target: ITPR2 (Inositol 1,4,5-Trisphosphate Receptor, Type 2 (ITPR2))

Binding Specificity: AA 1152-1164

Reactivity: Human, Monkey

Host: Goat

Clonality: Polyclonal

Conjugate: This ITPR2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Brand: IHC-plus™

Specificity: Human ITPR2. No cross-reactivity expected with other types of ITPR.

Predicted Reactivity: Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%) Panda, Bat, Dog, Bovine, Rabbit, Horse, Pig, Opossum (92%) Turkey, Chicken (85%).

Purification: Immunoaffinity purified

Immunogen: Synthetic peptide C-PIEESNILSPVQD from an internal region of human ITPR2 (NP_002214.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%), Panda, Bat, Dog, Bovine, Rabbit, Horse, Pig, Opossum (92%), Turkey, Chicken (85%).

Type of Immunogen: Synthetic peptide

Application Details

Application Notes: Approved: IHC, IHC-P (3.75 μg/mL), Peptide-ELISA (1:128000)

Usage: Immunohistochemistry: This antibody was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in  pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for this antibody was determined to be 3.75 μg/mL.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Tris-buffered saline,  pH 7.3, 0.5 % BSA, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Minimize freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for ITPR2

Target: ITPR2 (Inositol 1,4,5-Trisphosphate Receptor, Type 2 (ITPR2))

Alternative Name: ITPR2 / IP3 Receptor Type 2 (ITPR2 Products)

Synonyms: AI649341 antibody, InsP3R-2 antibody, InsP3R-5 antibody, Ip3r2 antibody, Itpr5 antibody, insP3R2 antibody, IP3R2 antibody, inositol 1,4,5-trisphosphate receptor type 2 antibody, inositol 1,4,5-triphosphate receptor 2 antibody, inositol 1,4,5-trisphosphate receptor, type 2 antibody, ITPR2 antibody, Itpr2 antibody

Background: Name/Gene ID: ITPR2
Subfamily: Inositol 1,4,5-triphosphate receptor
Family: Ion Channel

Synonyms: ITPR2, IP3R 2, InsP3R2, IP3R2, InsP3R type II, IP3 receptor, InsP3R type 2, IP3 receptor isoform 2, Type 2 InsP3 receptor

Gene ID: 3709

NCBI Accession: NP_002214

UniProt: Q14571

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma