ERCC6 antibody (N-Term)

Catalog No. ABIN4886573

Product Details anti-ERCC6 Antibody

Target: ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))

Binding Specificity: AA 160-205, N-Term

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERCC6 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for DNA excision repair protein ERCC-6(ERCC6) detection. Tested with WB in Human,Rat.

Sequence: QAATSRDINR KLDSVKRQKY NKEQQLKKIT AKQKHLQAIL GGAEVK

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for DNA excision repair protein ERCC-6(ERCC6) detection. Tested with WB in Human,Rat.
Gene Name: ERCC excision repair 6, chromatin remodeling factor
Protein Name: DNA excision repair protein ERCC-6

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human CSB (160-205aa QAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHLQAILGGAEVK).

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for ERCC6

Target: ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))

Alternative Name: ERCC6 (ERCC6 Products)

Synonyms: ARMD5 antibody, CKN2 antibody, COFS antibody, COFS1 antibody, CSB antibody, RAD26 antibody, UVSS1 antibody, 4732403I04 antibody, C130058G22Rik antibody, ercc6 antibody, Ercc6 antibody, ERCC excision repair 6, chromatin remodeling factor antibody, excision repair cross-complementing rodent repair deficiency, complementation group 6 antibody, excision repair cross-complementation group 6 antibody, DNA excision repair protein ERCC-6 antibody, ERCC6 antibody, Ercc6 antibody, ercc6 antibody, LOC100719487 antibody

Background: DNA excision repair protein ERCC-6 (also CS-B protein) is a protein that in humans is encoded by the ERCC6 gene. This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3' splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3, which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene.

Synonyms: ARMD 5 | ARMD5 | CKN 2 | CKN2 | COFS | COFS1 | CSB | ERCC 6 | ERCC6 | RAD26 | UVSS1 | Q03468

Gene ID: 2074

UniProt: Q03468

Pathways: DNA Damage Repair, Chromatin Binding