KEAP1 antibody (C-Term)
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- Target See all KEAP1 Antibodies
- KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
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Binding Specificity
- C-Term
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Reactivity
- Human, Pig, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This KEAP1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- Reacts with KEAP1 from human, pig, guinea pig, sheep and other species (due to 100 % sequence homology)
- Purification
- Purified (protein A)
- Immunogen
- Synthetic peptide of derived from C terminal part of human KEAP1.
- Top Product
- Discover our top product KEAP1 Primary Antibody
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- Application Notes
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Working dilution: Optimal dilutions should be determined by the end user.
The following are guidelines only:
WB(1:500 - 1:200) ICC/ IF(1:200 - 1:1000) - Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Must be reconstituted in distilled water.
- Concentration
- 1 mg/mL
- Buffer
- Tris 0,1M, glycine 0,1M
- Storage
- 4 °C/-20 °C
- Storage Comment
- Short term storage at+4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
- Expiry Date
- 6 months
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- Target
- KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
- Alternative Name
- KEAP1 (KEAP1 Products)
- Synonyms
- INrf2 antibody, KLHL19 antibody, INRF2 antibody, mKIAA0132 antibody, Inrf2 antibody, fb36f11 antibody, keap1 antibody, wu:fb36f11 antibody, KEAP1 antibody, klhl19 antibody, zgc:171654 antibody, kelch like ECH associated protein 1 antibody, kelch-like ECH-associated protein 1 antibody, Kelch-like ECH-associated protein 1 antibody, kelch-like ECH-associated protein 1a antibody, kelch like ECH associated protein 1 L homeolog antibody, kelch-like ECH-associated protein 1b antibody, KEAP1 antibody, Keap1 antibody, keap1a antibody, keap1 antibody, keap1.L antibody, keap1b antibody
- Background
- Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
- Gene ID
- 9817
- UniProt
- Q14145
- Pathways
- Maintenance of Protein Location
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