Prosaposin antibody (PSAP)

Details for Product anti-PSAP Antibody No. ABIN4889440, Supplier: Log in to see
Antigen
  • GLBA
  • SAP1
  • AI037048
  • SGP-1
  • SGP1A
  • cb759
  • wu:fa14a06
  • wu:fb36e02
  • wu:fb58g07
  • prosaposin
  • PSAP
  • Psap
  • psap
  • LOC100011417
  • LOC100304726
  • LOC100526719
Alternatives
anti-Humain Prosaposin antibody pour Western Blotting
Reactivity
Human
35
4
2
Host
Rabbit
26
9
Clonality
Polyclonal
Conjugate
This Prosaposin antibody is un-conjugated
3
3
3
1
1
1
Application
ELISA, Immunocytochemistry (ICC), Western Blotting (WB)
22
19
16
12
4
3
3
3
2
2
2
Options
Supplier
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Immunogen Synthetic peptide derived from an internal domain of human PSAP
Specificity Reacts with human Saposin-B
Cross-Reactivity (Details) May cross react with proteins from other species due to sequence homology
Purification Purified (protein A)
Plasmids, Primers & others Plasmids, Primers & others Prosaposin products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Proactivator Polypeptide Domain Saposin-B (PSAP) (PSAP Antibody Abstract)
Background The lysosomal degradation of sphingolipids takes place by the sequential action of specific hydrolases. Some of these enzymes require specific low-molecular mass, non-enzymic proteins: the sphingolipids activator proteins (coproteins). Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase and galactosylceramide by beta-galactosylceramidase. Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A, GM1 gangliosides by beta-galactosidase and globotriaosylceramide by alpha-galactosidase A. Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator.
Gene ID 5660
UniProt P07602
Pathways Positive Regulation of Endopeptidase Activity
Application Notes

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC1:200 - 1:1 000 WB1:500 - 1:5 000

Restrictions For Research Use only
Format Lyophilized
Reconstitution Must be reconstituted in distilled water to reach 1 mg/mL.
Concentration 1 mg/mL
Buffer Tris 0,1M, glycine 0,1M, sucrose 2 %
Storage 4 °C/-20 °C
Storage Comment Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
Expiry Date 24 months
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