TERT antibody (AA 222-298)

Catalog No. ABIN4902350

Product Details anti-TERT Antibody

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Binding Specificity: AA 222-298

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TERT antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: TERT is a protein encoded by the TERT gene which is approximately 126,9 kDa. TERT is localised to the nucleus. It is involved in chromosome maintenance, telomere C-strand synthesis, signalling by Wnt and embryonic stem cell differentiation pathways. It is a ribonucleoprotein polymerase that maintains telomere ends by the addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence. TERT is expressed in the blood, lung, liver, skin and nervous system. Mutations in the TERT gene may result in aplastic anemia. STJ98964 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody detects endogenous TERT.

Specificity: The antibody detects endogenous TERT.

Characteristics: Rabbit Polyclonal to TERT.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthetic peptide from human TERT protein.

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000
ELISA 1:10000-20000

Comment:

Expressed at a high level in thymocyte subpopulations, at an intermediate level in tonsil T-lymphocytes, and at a low to undetectable level in peripheral blood T-lymphocytes.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for TERT

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Alternative Name: TERT (TERT Products)

Synonyms: CMM9 antibody, DKCA2 antibody, DKCB4 antibody, EST2 antibody, PFBMFT1 antibody, TCS1 antibody, TP2 antibody, TRT antibody, hEST2 antibody, hTRT antibody, chTERT antibody, Tert antibody, ATTERT antibody, F5E19.190 antibody, F5E19_190 antibody, telomerase reverse transcriptase antibody, tert antibody, TR antibody, est2 antibody, tcs1 antibody, telomerase antibody, tert-A antibody, tp2 antibody, trt antibody, xTERT antibody, telomerase reverse transcriptase antibody, Telomerase Reverse Transcriptase antibody, Tertp antibody, Telomerase catalytic subunit antibody, telomerase reverse transcriptase L homeolog antibody, TERT antibody, trt-1 antibody, Tert antibody, tert antibody, CMU_003490 antibody, VDBG_04487 antibody, GL50803_16225 antibody, tert.L antibody

Molecular Weight: 126kDa

Gene ID: 7015

UniProt: O14746

Pathways: Telomere Maintenance