GRIN2B antibody (Tyr1474)

Catalog No. ABIN540488

Product Details anti-GRIN2B Antibody

Target: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Binding Specificity: Tyr1474

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIN2B antibody is un-conjugated

Application: Immunofluorescence (IF)

Purpose: Rabbit polyclonal antibody raised against synthetic peptide of GRIN2B.

Sequence: HVYEK

Specificity: NMDAR2B (Ab-1472) antibody detects endogenous levels of total NMDAR2B protein.

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Antibody Reactive Against Synthetic Peptide.

Immunogen: A synthetic peptide (conjugated with KLH) corresponding to residues surrounding Y1474 of human GRIN2B.

Application Details

Application Notes: Immunofluorescence (1:100-1:200)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS (without Mg²⁺ and Ca²⁺), 150 mM NaCl, pH 7.4 (50 % glycerol, 0.02 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-GRIN2B antibody (ABIN540488)

Chazot: "The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies." in: Current medicinal chemistry, Vol. 11, Issue 3, pp. 389-96, (2004) (PubMed).

Kakegawa, Tsuzuki, Iino, Ozawa: "Functional NMDA receptor channels generated by NMDAR2B gene transfer in rat cerebellar Purkinje cells." in: The European journal of neuroscience, Vol. 17, Issue 4, pp. 887-91, (2003) (PubMed).

Babb, Ying, Mikuni, Nishiyama, Drazba, Bingaman, Wyllie, Wylie, Yacubova: "Brain plasticity and cellular mechanisms of epileptogenesis in human and experimental cortical dysplasia." in: Epilepsia, Vol. 41 Suppl 6, pp. S76-81, (2000) (PubMed).

Target Details for GRIN2B

Target: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Alternative Name: NMDAR2B (GRIN2B Products)

Synonyms: NMDAR2B antibody, GluN2B antibody, MRD6 antibody, NR2B antibody, hNR3 antibody, nmdar2b antibody, nr2b antibody, AW490526 antibody, Nmdar2b antibody, glutamate ionotropic receptor NMDA type subunit 2B antibody, glutamate receptor, ionotropic, N-methyl D-aspartate 2B L homeolog antibody, glutamate receptor, ionotropic, NMDA2B (epsilon 2) antibody, GRIN2B antibody, Grin2b antibody, grin2b.L antibody

Gene ID: 2904

Pathways: Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity