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KEAP1 antibody (AA 25-205)

KEAP1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN4951533
  • Target See all KEAP1 Antibodies
    KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
    Binding Specificity
    • 15
    • 15
    • 15
    • 14
    • 10
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 25-205
    Reactivity
    • 80
    • 57
    • 29
    • 20
    • 18
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    Human
    Host
    • 82
    • 7
    • 1
    Rabbit
    Clonality
    • 82
    • 8
    Polyclonal
    Conjugate
    • 41
    • 9
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This KEAP1 antibody is un-conjugated
    Application
    • 77
    • 43
    • 32
    • 26
    • 26
    • 15
    • 9
    • 7
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Purification
    Antigen affinity
    Immunogen
    Amino acids 25-205 of human KEAP1 were used as the immunogen for the KEAP1 antibody.
    Isotype
    IgG
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    Discover our top product KEAP1 Primary Antibody
  • Application Notes
    Optimal dilution of the KEAP1 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Storage
    -20 °C
    Storage Comment
    After reconstitution, the KEAP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
    Alternative Name
    KEAP1 (KEAP1 Products)
    Synonyms
    INrf2 antibody, KLHL19 antibody, INRF2 antibody, mKIAA0132 antibody, Inrf2 antibody, fb36f11 antibody, keap1 antibody, wu:fb36f11 antibody, KEAP1 antibody, klhl19 antibody, zgc:171654 antibody, kelch like ECH associated protein 1 antibody, kelch-like ECH-associated protein 1 antibody, Kelch-like ECH-associated protein 1 antibody, kelch-like ECH-associated protein 1a antibody, kelch like ECH associated protein 1 L homeolog antibody, kelch-like ECH-associated protein 1b antibody, KEAP1 antibody, Keap1 antibody, keap1a antibody, keap1 antibody, keap1.L antibody, keap1b antibody
    Background
    KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 is a protein that in humans is encoded by the KEAP1 gene. Keap1 contains a central BTB/POZ domain and a C-terminal double glycine repeat (DGR), or Kelch, module. Keap1 has been shown to interact with Nrf2, a master regulator of the antioxidant response, which is important for the amelioration of oxidative stress. In the presence of the electrophilic agent diethylmalate, Nrf2 activity is released from Keap1 and Nrf2 translocate to the nucleus. Under quiescent conditions, Nrf2 is anchored in the cytoplasm through binding to Keap1, which, in turn, facilitates the ubiquitination and subsequent proteolysis of Nrf2. Because Nrf2 activation leads to a coordinated antioxidant and anti-inflammatory response, and Keap1 represses Nrf2 activation, Keap1 has become a very attractive drug target.
    UniProt
    Q14145
    Pathways
    Maintenance of Protein Location
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