AXL antibody (AA 838-872)

Catalog No. ABIN3030090

Product Details anti-AXL Antibody

Target: AXL (AXL Receptor tyrosine Kinase (AXL))

Binding Specificity: AA 838-872

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AXL antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antigen affinity purified

Immunogen: This AXL antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 838-872 amino acids from the C-terminal region of human AXL.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the AXL antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the AXL antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for AXL

Target: AXL (AXL Receptor tyrosine Kinase (AXL))

Alternative Name: AXL (AXL Products)

Synonyms: JTK11 antibody, UFO antibody, AI323647 antibody, Ark antibody, Tyro7 antibody, Ufo antibody, AXL receptor tyrosine kinase antibody, Axl receptor tyrosine kinase antibody, AXL antibody, Axl antibody

Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3, but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor. [UniProt]

UniProt: P30530

Pathways: RTK Signaling, Cellular Response to Molecule of Bacterial Origin