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MAP2K3 antibody
MAP2K3
Reactivity: Human, Mouse, Rat
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-MAP2K3 Antibody
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Target
See all MAP2K3 Antibodies
MAP2K3
(Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
Reactivity
All reactivities for MAP2K3 antibodies
Human, Mouse, Rat
Host
All hosts for MAP2K3 antibodies
Rabbit
Clonality
All clonalities for MAP2K3 antibodies
Polyclonal
Conjugate
All conjugates for MAP2K3 antibodies
This MAP2K3 antibody is un-conjugated
Application
All applications for MAP2K3 antibodies
Western Blotting (WB)
Specificity
This antibody detects endogenous levels of MEK-3 protein. (region surrounding Leu215)
Cross-Reactivity (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Purification
Affinity chromatography
Purity
> 95 % by SDS-PAGE
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Alternatives
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Application Details
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Application Notes
Western Blot: 1/500 - 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Concentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for MAP2K3
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Target
MAP2K3
(Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
Alternative Name
MAP2K3 (MAP2K3 Products )
Synonyms
MAPKK3 antibody, MEK3 antibody, MKK3 antibody, PRKMK3 antibody, SAPKK-2 antibody, SAPKK2 antibody, AW212142 antibody, Prkmk3 antibody, mMKK3b antibody, Mkk3 antibody, mitogen-activated protein kinase kinase 3 antibody, mitogen activated protein kinase kinase 3 antibody, MAP kinase activator XMEK3 antibody, MAP2K3 antibody, Map2k3 antibody, map2k3 antibody
Background
The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinaseegulatory threonine and tyrosine residues present in thehr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK5, whereas MEK-6hosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.Synonyms: Dual specificity mitogen-activated protein kinase kinase 3, MAP kinase kinase 3, MAPKK 3, MEK3, MKK3
Molecular Weight
approx. 39 kDa
Gene ID
5606
NCBI Accession
NP_002747
UniProt
P46734
Pathways
MAPK Signaling , TLR Signaling , Activation of Innate immune Response , Toll-Like Receptors Cascades , Autophagy , Signaling Events mediated by VEGFR1 and VEGFR2
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