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CDC25A antibody (AA 190-484)
CDC25A
Reactivity: Human
WB, IHC
Host: Mouse
Monoclonal
ABM4A46
unconjugated
Product Details anti-CDC25A Antibody
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Target
See all CDC25A Antibodies
CDC25A
(Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A))
Binding Specificity
All epitopes for CDC25A antibodies
AA 190-484
Reactivity
All reactivities for CDC25A antibodies
Human
Host
All hosts for CDC25A antibodies
Mouse
Clonality
All clonalities for CDC25A antibodies
Monoclonal
Conjugate
All conjugates for CDC25A antibodies
This CDC25A antibody is un-conjugated
Application
All applications for CDC25A antibodies
Western Blotting (WB), Immunohistochemistry (IHC)
Purification
Protein G Chromatography
Immunogen
A partial length recombinant CDC25A protein (amino acids 190-484) was used as the immunogen for this antibody.
Clone
ABM4A46
Isotype
IgG2b kappa
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Discover our top product CDC25A Primary Antibody
Alternatives
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Application Details
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Application Notes
WB: 2-4 μg/mL, IHC: 5 μg/mL
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
PBS containing 0.05 % BSA, PH 7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Target Details for CDC25A
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Target
CDC25A
(Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A))
Alternative Name
CDC25A (CDC25A Products )
Synonyms
cdc25a2 antibody, cdc25A antibody, sb:cb317 antibody, CDC25A2 antibody, D9Ertd393e antibody, cell division cycle 25A antibody, cell division cycle 25B antibody, cell division cycle 25A S homeolog antibody, CDC25A antibody, cdc25a antibody, cdc25b antibody, Cdc25a antibody, cdc25a.S antibody
Background
CDC25A is a dual specificity (tyr/thr) phosphatase and a putative upregulated c-Myc target gene. It is a regulator of the cell cycle required for progression from G1 to S phase. CDC25A is a member of the CDC25 family of phosphatases. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. Overexpression of CDC25A bypassed the mechanism of cell cycle arrest, leading to enhanced DNA damage and decreased cell survival. Specific degradation of CDC25A is identified as part of the DNA damage checkpoint mechanism and suggested how CDC25A overexpression in human cancers might contribute to tumorigenesis.
Molecular Weight
59 kDa
Gene ID
993
UniProt
P30304
Pathways
Cell Division Cycle , Mitotic G1-G1/S Phases , M Phase
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