CRHR2 antibody (AA 1-200)

Catalog No. ABIN5027120

Product Details anti-CRHR2 Antibody

Target: CRHR2 (Corticotropin Releasing Hormone Receptor 2 (CRHR2))

Binding Specificity: AA 1-200

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRHR2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogen: A partial length recombinant CRHR2 protein (amino acids 1-200) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 0.5-2.0 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for CRHR2

Target: CRHR2 (Corticotropin Releasing Hormone Receptor 2 (CRHR2))

Alternative Name: CRHR2 (CRHR2 Products)

Synonyms: CRF-RB antibody, CRF2 antibody, CRFR2 antibody, HM-CRF antibody, CRF-R2 antibody, CRFR2alpha antibody, CRFR2beta antibody, Crfr2 antibody, Crf2r antibody, CRH-R2 antibody, crhr2-A antibody, corticotropin releasing hormone receptor 2 antibody, corticotropin releasing hormone receptor 2 S homeolog antibody, CRHR2 antibody, Crhr2 antibody, crhr2.S antibody

Background: CRHR2 (CRF2R, CRH2R) (corticotropin releasing hormone receptor 2) belongs to the G-protein coupled receptor 2 family. This receptor has high affinity for corticotropin releasing hormone (CRH) and may also bind to CRH-related peptides, such as, urocortin. The human CRHR2 gene contains 12 exons. Three major functional isoforms have been reported: alpha, beta and gamma encoded by transcripts with alternative first exons which differ from each other by signal sequence and extra-cellular domain. CRH is synthesized in the hypothalamus and plays an important role in coordinating the endocrine, autonomic and behavioral responses to stress and immune challenge. CRHR2 has high expression in brain, caudate nucleus, cerebrum, colon, endometrium, etc.

Molecular Weight: 46 kDa

Gene ID: 1395

UniProt: Q13324

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Feeding Behaviour