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NLRP3 antibody (AA 150-385)
NLRP3
Reactivity: Human, Mouse
WB, IHC
Host: Mouse
Monoclonal
ABM2D48
unconjugated
Product Details anti-NLRP3 Antibody
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Target
See all NLRP3 Antibodies
NLRP3
(NLR Family, Pyrin Domain Containing 3 (NLRP3))
Binding Specificity
All epitopes for NLRP3 antibodies
AA 150-385
Reactivity
All reactivities for NLRP3 antibodies
Human, Mouse
Host
All hosts for NLRP3 antibodies
Mouse
Clonality
All clonalities for NLRP3 antibodies
Monoclonal
Conjugate
All conjugates for NLRP3 antibodies
This NLRP3 antibody is un-conjugated
Application
All applications for NLRP3 antibodies
Western Blotting (WB), Immunohistochemistry (IHC)
Purification
Protein G Chromatography
Immunogen
A partial length recombinant NALP3 protein (amino acids 150-385) was used as the immunogen for this antibody.
Clone
ABM2D48
Isotype
IgG2b kappa
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Discover our top product NLRP3 Primary Antibody
Alternatives
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anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 15-120) antibody
NLRP3
Reactivity: Human, Mouse, Rat, Dog
WB, ELISA, IHC (p), FACS, IF (p), ICC, IF (cc), IHC (fro)
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
WB: 6-8 μg/mL, IHC: 5 μg/mL
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
PBS containing 0.05 % BSA, PH 7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Target Details for NLRP3
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Target
NLRP3
(NLR Family, Pyrin Domain Containing 3 (NLRP3))
Alternative Name
NALP3 (NLRP3 Products )
Synonyms
CIAS1 antibody, Nalp3 antibody, avp antibody, cias1 antibody, nalp3 antibody, pypaf1 antibody, agtavprl antibody, AGTAVPRL antibody, AII antibody, AVP antibody, C1orf7 antibody, CLR1.1 antibody, FCAS antibody, FCU antibody, MWS antibody, NALP3 antibody, PYPAF1 antibody, AII/AVP antibody, Cias1 antibody, Mmig1 antibody, Pypaf1 antibody, NLR family pyrin domain containing-like antibody, NLR family pyrin domain containing 3 antibody, NLR family, pyrin domain containing 3 L homeolog antibody, NLR family, pyrin domain containing 3 antibody, NLRPL antibody, NLRP3 antibody, nlrp3.L antibody, Nlrp3 antibody
Background
NALP3 (NACHT, LRR and PYD domains-containing protein 3), otherwise known as cryopyrin, is a member of the NLR (Nod-like-receptors) family. This is a pyrin-like protein, having N-terminal CARD or pyrin domains needed for homotypic protein protein interaction, an intermediate nucleotide binding self oligomerization NACHT domain and a C-terminal domain containing leucine rich repeats (LRRs). NALP3 is a key component of innate immunity and its expression is restricted to immune cells and chondrocytes. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kB signaling, and it plays an important role in the regulation of inflammation, the immune response, and apoptosis.
Molecular Weight
120 kDa
Gene ID
114548
UniProt
Q96P20
Pathways
Cellular Response to Molecule of Bacterial Origin , Positive Regulation of Endopeptidase Activity , Inflammasome
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