SOX10 antibody (AA 115-269)

Catalog No. ABIN5027534

Product Details anti-SOX10 Antibody

Target: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Binding Specificity: AA 115-269

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SOX10 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein G Chromatography

Immunogen: A partial length recombinant SOX-10 protein (amino acids 115-269) was used as the immunogen for this antibody.

Clone: ABM4E24

Isotype: IgG2b kappa

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for SOX10

Target: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Alternative Name: SOX10 (SOX10 Products)

Synonyms: DOM antibody, PCWH antibody, WS2E antibody, WS4 antibody, WS4C antibody, SOX-10 antibody, SOX10 antibody, dom antibody, ws4 antibody, Dom antibody, Sox21 antibody, SOX9 antibody, cls/sox10 antibody, zgc:100757 antibody, SRY-box 10 antibody, SRY box 10 antibody, SRY-box 10 L homeolog antibody, SRY (sex determining region Y)-box 10 antibody, SOX10 antibody, Sox10 antibody, sox10.L antibody, sox10 antibody

Background: SOX10 is a transcription factor that belongs to the high mobility group (HMG) box super family of DNA-binding proteins. It is located at 22q13.1 and is highly conserved in vertebrates. SOX10 is expressed in many different cell types and tissues and implicated in neural crest development, nervous system neurogenesis, as well as differentiation of oligodendrocyte, glia and melanocytes. It modulates other transcription factors including PAX3 forming a complex and acts as a nucleocytoplasmic shuttle protein in neural crest and oligodendrocyte development. The level of expression of SOX10 plays pivotal regulatory role both in tumor progression and suppression. Its elevated expression, possess tumor-promoting activities in several malignancies including melanoma and gliomas. Decreased expression of SOX10 promotes tumor cell growth and focal adhesions of Merlin-null schwannoma cells. SOX10 may also function as a tumor suppressor by inducing tumor cell apoptosis, inhibiting invasion, regulating cell EMT and stemness through suppressing Wnt/Beta-catenin signaling. Mutations of the Sox10 gene are known to cause various combinations of hearing loss and pigmentation defects in humans such as Waardenburg syndrome, a rare auditory-pigmentary disorder that generates varying combinations of hearing loss and pigmentation defects.

Molecular Weight: 50 kDa

Gene ID: 6663

UniProt: P56693

Pathways: Chromatin Binding