TBPL1 antibody

Catalog No. ABIN5027797

Product Details anti-TBPL1 Antibody

Target: TBPL1 (TBP-Like 1 (TBPL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TBPL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Protein G Chromatography

Immunogen: Full length recombinant TRF2 protein was used as the immunogen for this antibody.

Clone: ABM10H3

Isotype: IgG1 kappa

Application Details

Application Notes: WB: 2-4 μg/mL, IHC: 5 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for TBPL1

Target: TBPL1 (TBP-Like 1 (TBPL1))

Alternative Name: TRF2 (TBPL1 Products)

Synonyms: MGC:8389 antibody, MGC:9620 antibody, STUD antibody, TLF antibody, TLP antibody, TRF2 antibody, tlf antibody, 4732475G08 antibody, AW011832 antibody, AW491032 antibody, D18347 antibody, STD antibody, TRP antibody, Tlp antibody, tlp antibody, trf antibody, trf2 antibody, trp antibody, zgc:92340 antibody, TATA binding protein 1 antibody, TFIID-1 antibody, TRANSCRIPTION FACTOR IID-1 antibody, TATA-box binding protein like 1 antibody, TATA-binding protein 1 antibody, TATA-box binding protein like 1 L homeolog antibody, TATA box binding protein-like 1 antibody, TBP-like 1 antibody, TATA binding protein 1 antibody, TBPL1 antibody, tbp1 antibody, tbpl1.L antibody, tbpl1 antibody, Tbpl1 antibody, TBP1 antibody

Background: TRF2 (Telomere Repeat Binding Factor 2), a subunit of the shelterin complex, binds to duplex telomeric DNA and plays a crucial role in telomere protection. TRF2 contains an N-terminal basic domain rich in glycines and arginines (the GAR domain), a central TRFH dimerization domain, a flexible linker region and a C-terminal Myb-like DNA binding domain. TRF2 undergoes extensive post-translational modification, which in turn regulates its stability, DNA binding and cellular localization. Ubiquitylation of TRF2 by Siah1, an E3 ligase, promotes TRF2 degradation and replicative senescence of human primary fibroblasts. TRF2 is phosphorylated in response to DNA damage and this phosphorylation has been implicated in DNA double strand break repair.

Molecular Weight: 50 kDa

Gene ID: 7014

UniProt: Q15554