TLR4 antibody (APC)
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- Target See all TLR4 Antibodies
- TLR4 (Toll-Like Receptor 4 (TLR4))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This TLR4 antibody is conjugated to APC
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Application
- Flow Cytometry (FACS)
- Purification
- Protein G Chromatography
- Immunogen
- This antibody was developed by immunizing mice with Ba/F3 cell line expressing human TLR4 cell surface antigen.
- Clone
- HTA125
- Isotype
- IgG2a
- Top Product
- Discover our top product TLR4 Primary Antibody
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- Application Notes
- FACS: 0.5-1 μg/10^6
- Restrictions
- For Research Use only
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- Concentration
- 0.2 mg/mL
- Buffer
- PBS containing 0.05 % BSA, PH 7.4
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store the antibody at 4°C, stable for 6 months.
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- Target
- TLR4 (Toll-Like Receptor 4 (TLR4))
- Alternative Name
- TLR4 (TLR4 Products)
- Synonyms
- ARMD10 antibody, CD284 antibody, TLR-4 antibody, TOLL antibody, Lps antibody, Ly87 antibody, Ran/M1 antibody, Rasl2-8 antibody, toll like receptor 4 antibody, toll-like receptor 4 antibody, TLR4 antibody, Tlr4 antibody
- Background
- TLR4 (Toll-like receptor-4) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. It primarily mediates cellular signaling induced by Gram negative bacteria. TLR4 is highly specific for LPS and it is associated with CD14, a co-receptor for LPS. The downstream signaling pathway of TLR4 leads to the activation of NF-kappaB through myeloid differentiation protein (MyD88) and IL-1 receptor-associated kinase in various cell types. Keratinocytes express TLR4 at the mRNA and protein levels whereas TLR4 are also present in the normal human epidermis in vivo and their expression is regulated by microbial components. TLR4 is expressed on CD4+ T cells as well, the functional significance of which is unclear.
- Gene ID
- 7099
- UniProt
- O00206
- Pathways
- TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins
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