NOXA antibody

Catalog No. ABIN531994

Product Details anti-NOXA Antibody

Target: NOXA (PMAIP1) (Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NOXA antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Purpose: Mouse monoclonal antibody raised against full length recombinant PMAIP1.

Cross-Reactivity: Human

Purification: Purified

Immunogen: Recombinant GST fusion protein corresponding to full length human PMAIP1.

Clone: 114C307-1

Isotype: IgG1

Application Details

Application Notes: The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.05 % BSA, 0.05 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-NOXA antibody (ABIN531994)

Zhang, Hao, Hu, Ye, Xie, Thorne, Hersey, Zhang: "Inhibition of apoptosis facilitates necrosis induced by cisplatin in gastric cancer cells." in: Anti-cancer drugs, Vol. 19, Issue 2, pp. 159-66, (2008) (PubMed).

Tahir, Yang, Anderson, Morgan-Lappe, Sarthy, Chen, Warner, Ng, Fesik, Elmore, Rosenberg, Tse: "Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737." in: Cancer research, Vol. 67, Issue 3, pp. 1176-83, (2007) (PubMed).

Simbulan-Rosenthal, Daher, Trabosh, Chen, Gerstel, Soeda, Rosenthal: "Id3 induces a caspase-3- and -9-dependent apoptosis and mediates UVB sensitization of HPV16 E6/7 immortalized human keratinocytes." in: Oncogene, Vol. 25, Issue 26, pp. 3649-60, (2006) (PubMed).

Xie, Jiang, Miao, Zhao, Zhimin, Qing, Zhu, Wu: "Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1." in: Nucleic acids research, Vol. 34, Issue 7, pp. 2046-55, (2006) (PubMed).

Yoshida, Takemura, Inoue, Miyashita, Ueda: "Inhibition of glutathione synthesis overcomes Bcl-2-mediated topoisomerase inhibitor resistance and induces nonapoptotic cell death via mitochondrial-independent pathway." in: Cancer research, Vol. 66, Issue 11, pp. 5772-80, (2006) (PubMed).

Target Details for NOXA

Target: NOXA (PMAIP1) (Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))

Alternative Name: NOXA (PMAIP1 Products)

Synonyms: TN3 antibody, PMAIP1 antibody, zgc:162379 antibody, APR antibody, NOXA antibody, Noxa antibody, phorbol-12-myristate-13-acetate-induced protein 1 antibody, PMAIP1 antibody, pmaip1 antibody, Pmaip1 antibody

Gene ID: 5366

Pathways: p53 Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus