p300 antibody (pSer89)

Catalog No. ABIN537611

Product Details anti-p300 Antibody

Target: p300 (EP300) (E1A Binding Protein P300 (EP300))

Binding Specificity: pSer89

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This p300 antibody is un-conjugated

Application: Dot Blot (DB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit polyclonal antibody raised against synthetic phosphopeptide of EP300.

Cross-Reactivity: Human

Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S89 of human EP300.

Application Details

Application Notes: Dot Blot (1:500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-p300 antibody (ABIN537611)

Jin, Jeon, Li, Lee, Choi, Kim, Lee, Bae: "Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation." in: The Journal of biological chemistry, Vol. 279, Issue 28, pp. 29409-17, (2004) (PubMed).

Finlan, Hupp: "The N-terminal interferon-binding domain (IBiD) homology domain of p300 binds to peptides with homology to the p53 transactivation domain." in: The Journal of biological chemistry, Vol. 279, Issue 47, pp. 49395-405, (2004) (PubMed).

Dornan, Eckert, Wallace, Shimizu, Ramsay, Hupp, Ball: "Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53." in: Molecular and cellular biology, Vol. 24, Issue 22, pp. 10083-98, (2004) (PubMed).

Target Details for p300

Target: p300 (EP300) (E1A Binding Protein P300 (EP300))

Alternative Name: EP300 / P300 (EP300 Products)

Synonyms: KAT3B antibody, RSTS2 antibody, p300 antibody, A430090G16 antibody, A730011L11 antibody, p300 HAT antibody, E1A binding protein p300 antibody, histone acetyltransferase p300 antibody, EP300 antibody, LOC446056 antibody, ep300 antibody, Ep300 antibody

Gene ID: 2033

Pathways: p53 Signaling, Notch Signaling, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Regulation of Cell Size