IRS1 antibody (Internal Region)

Catalog No. ABIN541257

Product Details anti-IRS1 Antibody

Target: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Purpose: Rabbit polyclonal antibody raised against synthetic peptide of IRS1.

Cross-Reactivity: Human, Mouse

Immunogen: A synthetic peptide corresponding to internal region 16 amino acids of human IRS1.

Application Details

Application Notes: Western Blot (1-2 μg/mL)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.02 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-IRS1 antibody (ABIN541257)

Shamji, Nghiem, Schreiber: "Integration of growth factor and nutrient signaling: implications for cancer biology." in: Molecular cell, Vol. 12, Issue 2, pp. 271-80, (2003) (PubMed).

Giovannone, Scaldaferri, Federici, Porzio, Lauro, Fusco, Sbraccia, Borboni, Lauro, Sesti: "Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential." in: Diabetes/metabolism research and reviews, Vol. 16, Issue 6, pp. 434-41, (2001) (PubMed).

Ozes, Akca, Mayo, Gustin, Maehama, Dixon, Donner: "A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 8, pp. 4640-5, (2001) (PubMed).

Target Details for IRS1

Target: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Alternative Name: IRS1 (IRS1 Products)

Synonyms: HIRS-1 antibody, G972R antibody, IRS-1 antibody, IRS1IRM antibody, irs1 antibody, irsu antibody, IRS1 antibody, irs-1 antibody, irs1-a antibody, insulin receptor substrate 1 antibody, insulin receptor substrate 2 antibody, insulin receptor substrate 1 S homeolog antibody, IRS1 antibody, Irs1 antibody, irs2 antibody, irs1.S antibody

Gene ID: 3667

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process