GJB2 antibody (C-Term)

Catalog No. ABIN544540

Product Details anti-GJB2 Antibody

Target: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GJB2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit polyclonal antibody raised against synthetic peptide of GJB2.

Cross-Reactivity: Human, Mouse

Immunogen: A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human GJB2.

Application Details

Application Notes: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-GJB2 antibody (ABIN544540)

Alesutan, Sopjani, Munoz, Fraser, Kemp, Föller, Lang: "Inhibition of connexin 26 by the AMP-activated protein kinase." in: The Journal of membrane biology, Vol. 240, Issue 3, pp. 151-8, (2011) (PubMed).

Ohtsuka, Yuge, Kimura, Namba, Abe, Van Laer, Van Camp, Usami: "GJB2 deafness gene shows a specific spectrum of mutations in Japan, including a frequent founder mutation." in: Human genetics, Vol. 112, Issue 4, pp. 329-33, (2003) (PubMed).

Yotsumoto, Hashiguchi, Chen, Ohtake, Tomitaka, Akamatsu, Matsunaga, Shiraishi, Miura, Adachi, Kanzaki: "Novel mutations in GJB2 encoding connexin-26 in Japanese patients with keratitis-ichthyosis-deafness syndrome." in: The British journal of dermatology, Vol. 148, Issue 4, pp. 649-53, (2003) (PubMed).

Uyguner, Tukel, Baykal, Eris, Emiroglu, Hafiz, Ghanbari, Baserer, Yuksel-Apak, Wollnik: "The novel R75Q mutation in the GJB2 gene causes autosomal dominant hearing loss and palmoplantar keratoderma in a Turkish family." in: Clinical genetics, Vol. 62, Issue 4, pp. 306-9, (2002) (PubMed).

Target Details for GJB2

Target: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Alternative Name: GJB2 / Cx26 (GJB2 Products)

Synonyms: ppk antibody, cx26 antibody, dfna3 antibody, dfnb1 antibody, nsrd1 antibody, dfna3a antibody, dfnb1a antibody, MGC53062 antibody, connexin-26 antibody, GJB2 antibody, AI325222 antibody, Cnx26 antibody, Cx26 antibody, Gjb-2 antibody, CXN-26 antibody, CX26 antibody, DFNA3 antibody, DFNA3A antibody, DFNB1 antibody, DFNB1A antibody, HID antibody, KID antibody, NSRD1 antibody, PPK antibody, gap junction protein beta 2 L homeolog antibody, gap junction protein beta 2 antibody, gap junction protein, beta 2 antibody, gjb2.L antibody, GJB2 antibody, Gjb2 antibody

Gene ID: 2706

Pathways: Sensory Perception of Sound, Cell-Cell Junction Organization