PYCARD antibody (C-Term)

Catalog No. ABIN546787

Product Details anti-PYCARD Antibody

Target: PYCARD (PYD and CARD Domain Containing (PYCARD))

Binding Specificity: C-Term

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This PYCARD antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Goat polyclonal antibody raised against synthetic peptide of PYCARD.

Sequence: C-RESQSYLVED LERS

Specificity: This antibody is expected to recognize all three reported human isoforms according to NP_037390.2, NP_660183.1 and NP_660184.1.

Cross-Reactivity: Human

Immunogen: A synthetic peptide corresponding to C-terminus of human PYCARD.

Application Details

Application Notes: ELISA (1:32000)
Western Blot (1-3 μg/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-4 μg/mL)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: In Tris saline, pH 7.3 (0.5 % BSA, 0.02 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-PYCARD antibody (ABIN546787)

Ohtsuka, Ryu, Minamishima, Macip, Sagara, Nakayama, Aaronson, Lee: "ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway." in: Nature cell biology, Vol. 6, Issue 2, pp. 121-8, (2004) (PubMed).

Target Details for PYCARD

Target: PYCARD (PYD and CARD Domain Containing (PYCARD))

Alternative Name: CARD5 / PYCARD / ASC (PYCARD Products)

Synonyms: ASC antibody, CARD5 antibody, TMS antibody, TMS-1 antibody, TMS1 antibody, 9130417A21Rik antibody, Asc antibody, TNS1 antibody, masc antibody, asc1 antibody, zAsc antibody, zgc:109874 antibody, PYD and CARD domain containing antibody, PYCARD antibody, Pycard antibody, pycard antibody

Gene ID: 29108

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation, Inflammasome