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TPP1 antibody (C-Term)
TPP1
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-TPP1 Antibody
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Target
See all TPP1 Antibodies
TPP1
(Tripeptidyl Peptidase I (TPP1))
Binding Specificity
All epitopes for TPP1 antibodies
C-Term
Reactivity
All reactivities for TPP1 antibodies
Human
Host
All hosts for TPP1 antibodies
Rabbit
Clonality
All clonalities for TPP1 antibodies
Polyclonal
Conjugate
All conjugates for TPP1 antibodies
This TPP1 antibody is un-conjugated
Application
All applications for TPP1 antibodies
Western Blotting (WB)
Sequence
QHGAGLFDVT RGCHESCLDE EVEGQGFCSG PGWDPVTGWG TPNFPALLKT
Purification
Affinity purified
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human TPP1
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for TPP1
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Target
TPP1
(Tripeptidyl Peptidase I (TPP1))
Alternative Name
TPP1 (TPP1 Products )
Synonyms
cln2 antibody, fa01b09 antibody, im:7149243 antibody, wu:fa01b09 antibody, CLN2 antibody, LPIC antibody, TPP-1 antibody, TPP-I antibody, Cln2 antibody, tripeptidyl peptidase I antibody, tripeptidyl-peptidase 1 antibody, tripeptidyl peptidase 1 antibody, tpp1 antibody, NAEGRDRAFT_78259 antibody, MCYG_00184 antibody, MGYG_05881 antibody, MGYG_00757 antibody, TPP1 antibody, Tpp1 antibody
Background
This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. Alias Symbols: CLN2, GIG1, LPIC, SCAR7, TPP-1 Protein Size: 563
Gene ID
1200
NCBI Accession
NM_000391 , NP_000382
UniProt
O14773
Pathways
Cell Division Cycle , ER-Nucleus Signaling
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