PKLR antibody (N-Term)

Catalog No. ABIN5515040

Product Details anti-PKLR Antibody

Target: PKLR (Pyruvate Kinase, Liver and RBC (PKLR))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKLR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: TVDPAFRTRG NANTVWVDYP NIVRVVPVGG RIYIDDGLIS LVVQKIGPEG

Characteristics: This is a rabbit polyclonal antibody against PKLR. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human PKLR

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PKLR

Target: PKLR (Pyruvate Kinase, Liver and RBC (PKLR))

Alternative Name: PKLR (PKLR Products)

Synonyms: PK1 antibody, PKL antibody, PKR antibody, PKRL antibody, RPK antibody, Pklg antibody, wu:fd15e01 antibody, wu:fi37e08 antibody, pk1 antibody, PKLR antibody, Pk-1 antibody, Pk1 antibody, R-PK antibody, pklr antibody, pyruvate kinase L/R antibody, pyruvate kinase, liver and RBC antibody, pyruvate kinase, liver and RBC L homeolog antibody, pyruvate kinase liver and red blood cell antibody, pyruvate kinase PKLR-like antibody, PKLR antibody, Pklr antibody, pklr antibody, pklr.L antibody, LOC100621940 antibody

Background: The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.

Alias Symbols: PKLR, PK1, PKL,

Protein Interaction Partner: UBC, WWOX, SUMO4, CLEC4G, PCNA, OTUD5, USPL1, USP3, MYOC, KIF23, ARHGEF6, PXN, PAK1,

Protein Size: 574

Gene ID: 5313

UniProt: P30613

Pathways: Ribonucleoside Biosynthetic Process