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FZR1 antibody (N-Term)
FZR1
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-FZR1 Antibody
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Target
See all FZR1 Antibodies
FZR1
(Fizzy/cell Division Cycle 20 Related 1 (FZR1))
Binding Specificity
All epitopes for FZR1 antibodies
N-Term
Reactivity
All reactivities for FZR1 antibodies
Human
Host
All hosts for FZR1 antibodies
Rabbit
Clonality
All clonalities for FZR1 antibodies
Polyclonal
Conjugate
All conjugates for FZR1 antibodies
This FZR1 antibody is un-conjugated
Application
All applications for FZR1 antibodies
Western Blotting (WB)
Sequence
SKHGDRFIPS RAGANWSVNF HRINENEKSP SQNRKAKDAT SDNGKDGLAY
Characteristics
This is a rabbit polyclonal antibody against FZR. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Human FZR
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for FZR1
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Target
FZR1
(Fizzy/cell Division Cycle 20 Related 1 (FZR1))
Alternative Name
FZR (FZR1 Products )
Synonyms
CDH1-C antibody, FYR antibody, FZR antibody, CDH1 antibody, fzr1 antibody, CDC20C antibody, FZR2 antibody, HCDH antibody, HCDH1 antibody, AW108046 antibody, Cdh1 antibody, Fyr antibody, zgc:55450 antibody, fizzy and cell division cycle 20 related 1 antibody, fizzy/cell division cycle 20 related 1 antibody, fizzy-related protein homolog antibody, fizzy/cell division cycle 20 related 1 (Drosophila) antibody, fizzy/cell division cycle 20 related 1a antibody, Fzr1 antibody, CDH1-C antibody, FZR1 antibody, LOC100027495 antibody, LOC100179951 antibody, fzr1a antibody
Background
FZR is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Alias Symbols: FZR1, CDH1, FYR, FZR, KIAA1242, Protein Interaction Partner: ZC3HC1, CDC25A, CCNB1, UBE2S, UBE2C, PTTG1, UBE2D2, TP53, CDR2, UBE2K, ANAPC4, PDS1, STAU1, CDK2, CDC27, RACGAP1, FOXM1, HECW2, PHF8, BTRC, CCNA1, UBC, SOX2, SKP2, PLK1, CUL1, CUEDC2, CDC20, kif22, SIRT2, CLSPN, ANAPC11, CDC14B, VHL, PTEN, EYA1, DAXX, BUB Protein Size: 496
Gene ID
51343
NCBI Accession
XP_005259630
UniProt
Q9UM11
Pathways
DNA Replication , Synthesis of DNA
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