TRAF3 antibody (C-Term)

Catalog No. ABIN5516052

Product Details anti-TRAF3 Antibody

Target: TRAF3 (TNF Receptor-Associated Factor 3 (TRAF3))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRAF3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MLMDQGSSRR HLGDAFKPDP NSSSFKKPTG EMNIASGCPV FVAQTVLENG

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TRAF3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRAF3

Target: TRAF3 (TNF Receptor-Associated Factor 3 (TRAF3))

Alternative Name: TRAF3 (TRAF3 Products)

Synonyms: CAP-1 antibody, CAP1 antibody, CD40bp antibody, CRAF1 antibody, IIAE5 antibody, LAP1 antibody, AI528849 antibody, T-BAM antibody, amn antibody, TNF receptor associated factor 3 antibody, TNF receptor-associated factor 3 antibody, Tnf receptor-associated factor 3 antibody, TRAF3 antibody, Traf3 antibody

Background: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.

Alias Symbols: CAP1, LAP1, CAP-1, CRAF1, IIAE5, CD40bp

Protein Size: 167

Gene ID: 7187

NCBI Accession: NM_001199427, NP_001186356

UniProt: Q13114

Pathways: NF-kappaB Signaling, Apoptosis, TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades