IFIH1 antibody (Middle Region)

Catalog No. ABIN5516827

Product Details anti-IFIH1 Antibody

Target: IFIH1 (Interferon Induced with Helicase C Domain 1 (IFIH1))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFIH1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PYQMEVAQPA LEGKNIIICL PTGSGKTRVA VYIAKDHLDK KKKASEPGKV IV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 85%, Human: 100%, Mouse: 92%, Rabbit: 93%, Rat: 92%

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human IFIH1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IFIH1

Target: IFIH1 (Interferon Induced with Helicase C Domain 1 (IFIH1))

Alternative Name: IFIH1 (IFIH1 Products)

Synonyms: MDA5 antibody, Hlcd antibody, IDDM19 antibody, MDA-5 antibody, RLR-2 antibody, 9130009C22Rik antibody, Helicard antibody, RGD1560496 antibody, interferon induced with helicase C domain 1 antibody, IFIH1 antibody, Ifih1 antibody

Background: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents, treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19.

Alias Symbols: AGS7, Hlcd, MDA5, MDA-5, RLR-2, IDDM19, SGMRT1

Protein Interaction Partner: USP21, USP3, UBC, NLRC5, APP, TSPAN6, MAVS, PCBP2, PIAS2, SUMO1, IDE,

Protein Size: 1025

Gene ID: 64135

NCBI Accession: NM_022168, NP_071451

UniProt: Q9BYX4

Pathways: Activation of Innate immune Response