SUN2 antibody (N-Term)

Catalog No. ABIN5516851

Product Details anti-SUN2 Antibody

Target: SUN2 (Sad1 and UNC84 Domain Containing 2 (SUN2))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUN2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RSQRLTRYSQ GDDDGSSSSG GSSVAGSQST LFKDSPLRTL KRKSSNMKRL

Characteristics: This is a rabbit polyclonal antibody against SUN2. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SUN2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SUN2

Target: SUN2 (Sad1 and UNC84 Domain Containing 2 (SUN2))

Alternative Name: SUN2 (SUN2 Products)

Synonyms: UNC84B antibody, B230369L08Rik antibody, C030011B15 antibody, Unc84b antibody, RGD1563141 antibody, Sad1 and UNC84 domain containing 2 antibody, SUN2 antibody, Sun2 antibody

Background: SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1, MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity.

Alias Symbols: SUN2, FRIGG, KIAA0668, RAB5IP, UNC84B,

Protein Interaction Partner: FBXW11, NRM, BTRC, UBC, WHSC1, RPS20, RAB5B, RAB5A, TP53BP1, C9orf3, SYNE1, SYNE2, AGO3, USP20, HGS, RAB5C,

Protein Size: 717

Gene ID: 25777

NCBI Accession: XP_005261558

UniProt: Q9UH99

Pathways: Maintenance of Protein Location, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection