RPA2 antibody (C-Term)

Catalog No. ABIN5517299

Product Details anti-RPA2 Antibody

Target: RPA2 (Replication Protein A2, 32kDa (RPA2))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPA2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SLVAFKIMPL EDMNEFTTHI LEVINAHMVL SKANSQPSAG RAPISNPGMS

Characteristics: This is a rabbit polyclonal antibody against RPA2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human RPA2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RPA2

Target: RPA2 (Replication Protein A2, 32kDa (RPA2))

Alternative Name: RPA2 (RPA2 Products)

Synonyms: REPA2 antibody, RPA32 antibody, 153194_at antibody, CG9273 antibody, Dmel\\CG9273 antibody, dRPA2 antibody, rpa antibody, zgc:109822 antibody, ik:tdsubc_2g1 antibody, xx:tdsubc_2g1 antibody, repa2 antibody, rpa32 antibody, RPA2 antibody, GB13976 antibody, LOC100230445 antibody, AA409079 antibody, AI325195 antibody, AU020965 antibody, RPA34 antibody, Rf-A2 antibody, replication protein A2 antibody, Replication protein A2 antibody, replication protein A2, 32kDa antibody, replication protein A 32 kDa subunit antibody, RPA2 antibody, Rpa2 antibody, rpa2 antibody, LOC725418 antibody, RPA2_2 antibody

Background: RPA2 functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair, it does not support chromosomal DNA replication and cell cycle progression through S- phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. FUNCTION: Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage.

Alias Symbols: RPA2, REPA2, RPA32, RPA34,

Protein Interaction Partner: HUWE1, APITD1, STRA13, FBXO18, UBC, PPP1R10, PPP1CC, POLR2E, POLA1, EXOSC10, PRDX1, NUMA1, NTHL1, NPM1, NONO, NCL, NBN, HNRNPM, PPP1R12A, MYO1E, MYO1C, MYH11, MYH10, MYH9, MYO1F, MTHFD1, MSH3, MSH2, MYO1B, MRE11A, MPG, MOV10, MNAT1, RAB8A, MAP4, CAPRIN1,

Protein Size: 358

Gene ID: 6118

Pathways: Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA