OAS3 antibody (C-Term)

Catalog No. ABIN5530213

Product Details anti-OAS3 Antibody

Target: OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))

Binding Specificity: AA 1056-1087, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OAS3 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This OAS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1056-1087 amino acids from the C-terminal region of human OAS3.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.56 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for OAS3

Target: OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))

Alternative Name: OAS3 (OAS3 Products)

Synonyms: p100 antibody, Oasl10 antibody, 2'-5'-oligoadenylate synthetase 3 antibody, 2'-5' oligoadenylate synthetase 3 antibody, OAS3 antibody, Oas3 antibody

Background: OAS3 is an interferon inducible protein that belongs to the 2-5A synthetase family, may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate. OAS3 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. The protein is present at high level in placenta trophoblast.

Molecular Weight: 121 kDa

Gene ID: 4940

UniProt: Q9Y6K5

Pathways: Hepatitis C