Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Immunogen
This PPP3CC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-47 amino acids from the N-terminal region of human PPP3CC.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CALNA3 antibody, CNA3 antibody, PP2Bgamma antibody, Calnc antibody, ppp3cc antibody, sb:cb767 antibody, si:dkey-21k4.5 antibody, calna3 antibody, cna3 antibody, pp2bgamma antibody, im:7163784 antibody, zgc:158685 antibody, protein phosphatase 3 catalytic subunit gamma antibody, protein phosphatase 3, catalytic subunit, gamma isoform antibody, protein phosphatase 3, catalytic subunit, gamma isozyme, a antibody, protein phosphatase 3, catalytic subunit, gamma isozyme antibody, protein phosphatase 3, catalytic subunit, gamma isozyme L homeolog antibody, protein phosphatase 3, catalytic subunit, gamma isozyme, b antibody, PPP3CC antibody, Ppp3cc antibody, ppp3cca antibody, ppp3cc antibody, ppp3cc.L antibody, ppp3ccb antibody
Background
Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha, calcineurin A-beta, and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95 % amino acid identity).