MBNL1 antibody (C-Term)
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- Target See all MBNL1 Antibodies
- MBNL1 (Muscleblind-like Protein 1 (MBNL1))
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Binding Specificity
- AA 255-284, C-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MBNL1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This MBNL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-284 amino acids from the C-terminal region of human MBNL1.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product MBNL1 Primary Antibody
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- Application Notes
- For WB starting dilution is: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Target
- MBNL1 (Muscleblind-like Protein 1 (MBNL1))
- Alternative Name
- MBNL1 (MBNL1 Products)
- Synonyms
- MBNL1 antibody, zgc:153954 antibody, Mbnl antibody, mKIAA0428 antibody, EXP antibody, EXP35 antibody, EXP40 antibody, EXP42 antibody, MBNL antibody, muscleblind like splicing regulator 1 antibody, muscleblind-like splicing regulator 1 antibody, muscleblind like splicing factor 1 antibody, MBNL1 antibody, mbnl1 antibody, Mbnl1 antibody
- Background
- Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.
- Molecular Weight
- 42 kDa
- Gene ID
- 4154
- UniProt
- Q9NR56
- Pathways
- Ribonucleoprotein Complex Subunit Organization
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