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PTPN3 antibody (AA 366-397)

PTPN3 Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5537377
  • Target See all PTPN3 Antibodies
    PTPN3 (Protein tyrosine Phosphatase, Non-Receptor Type 3 (PTPN3))
    Binding Specificity
    • 15
    • 7
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 366-397
    Reactivity
    • 37
    • 28
    • 19
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 39
    Rabbit
    Clonality
    • 39
    Polyclonal
    Conjugate
    • 16
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PTPN3 antibody is un-conjugated
    Application
    • 32
    • 13
    • 11
    • 11
    • 4
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
    Immunogen
    This PTPH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-397 amino acids from the Central region of human PTPH1.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PTPN3 Primary Antibody
  • Application Notes
    For WB starting dilution is: 1:1000

    For IHC-P starting dilution is: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    2 mg/mL
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    PTPN3 (Protein tyrosine Phosphatase, Non-Receptor Type 3 (PTPN3))
    Alternative Name
    PTPH1 (PTPN3 Products)
    Synonyms
    PTP-H1 antibody, PTPH1 antibody, 9530011I20Rik antibody, PTPCL antibody, protein tyrosine phosphatase, non-receptor type 3 antibody, PTPN3 antibody, Ptpn3 antibody
    Background
    Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation ?it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.
    Molecular Weight
    104 kDa
    Gene ID
    5774
    UniProt
    P26045
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