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NMDA 1 Receptor antibody (pSer890)

NMDA R1 Reactivity: Human, Rat, Mouse IHC (p), IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5540835
  • Target See all NMDA 1 Receptor (NMDA R1) Antibodies
    NMDA 1 Receptor (NMDA R1) (NMDA Receptor 1 (NMDA R1))
    Binding Specificity
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer890
    Reactivity
    • 19
    • 16
    • 15
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Rat, Mouse
    Host
    • 18
    • 5
    Rabbit
    Clonality
    • 18
    • 5
    Polyclonal
    Conjugate
    • 23
    This NMDA 1 Receptor antibody is un-conjugated
    Application
    • 19
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    The antibody detects endogenous levels of NMDAR1 only when phosphorylated at serine 890.
    Purification
    Affinity chromatography using epitope-specific peptide
    Immunogen
    Peptide sequence around phosphorylation site of Serine 890(A-S-S(p)-F-K) derived from Human NMDAR1 (KLH-conjugated)
    Top Product
    Discover our top product NMDA R1 Primary Antibody
  • Application Notes
    Immunohistochemistry on paraffin sections: 1:50~1:100. Immunofluorescence: 1:100~1:200.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Target
    NMDA 1 Receptor (NMDA R1) (NMDA Receptor 1 (NMDA R1))
    Alternative Name
    nmda receptor 1 (NMDA R1 Products)
    Synonyms
    CG2902 antibody, DMNMDAR1 antibody, DNMDAR-I antibody, DNmdar antibody, DmelNmdar1 antibody, Dmel\\CG2902 antibody, DrNR1 antibody, NMDA antibody, NMDA R1 antibody, NMDAR1 antibody, NMdar1 antibody, NR1 antibody, NRI antibody, Nmdar antibody, dNR1 antibody, dnmdar-I antibody, nmr antibody, NMDA receptor 1 antibody, Nmdar1 antibody
    Background
    NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.
    UniProt
    Q05586
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