c-MET antibody

Catalog No. ABIN5542211

This Rat Monoclonal antibody specifically detects c-MET in FACS and EIA. It exhibits reactivity toward Human.

Quick Overview for c-MET antibody (ABIN5542211)

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This c-MET antibody is un-conjugated

Application: Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Clone: BCI-3E7

Product Details anti-c-MET Antibody

Specificity: Recognizes c-Met. Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells.

Purification: Affinity Chromatography on Protein G

Immunogen: cDNA encoding Human c-Met

Isotype: IgG2b

Application Details

Application Notes: Flow Cytometry: 1.2 μg/10 6 cells. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.2

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for c-MET

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Alternative Name: hgf receptor

Background: C-MET is a receptor tyrosine kinase that is activated upon Hepatocyte Growth Factor (HGF) binding. c-MET is produced as a single-chain precursor and plays en essential role in embryonic development and wound healing. It belongs to the class of Singlepass type I membrane proteins and it is normally expressed by cells of epithelial origin while the expression of HGF is restricted to cells of mesenchymal origin in an almost perfect paracrine paradigm. Overexpression of c-MET can be found in several kinds of tumor progression.

UniProt: P08581

Pathways: RTK Signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor