HES1 antibody

Catalog No. ABIN5564238

Product Details anti-HES1 Antibody

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This HES1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Specificity: Recognizes human, mouse and rat HES1.

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purity: >95 % (SDS-PAGE)

Immunogen: Recombinant human Hes1 protein fused to a His-tag.

Clone: 7H11

Isotype: IgG2b

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: HEPES with 0.15M NaCl, 0.01 % BSA, 0.03 % sodium azide, and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for HES1

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Alternative Name: Hairy and Enhancer of Split 1 (HES1 Products)

Synonyms: HES-1 antibody, HHL antibody, HRY antibody, bHLHb39 antibody, Hry antibody, HAIRY1 antibody, c-hairy1A antibody, Xhairy1 antibody, hairy1 antibody, hes1 antibody, Xhairy-1 antibody, Xlh1 antibody, hes family bHLH transcription factor 1 antibody, hairy and enhancer of split 1 (Drosophila) antibody, hes family bHLH transcription factor 4 antibody, hes family bHLH transcription factor 1 S homeolog antibody, hes family bHLH transcription factor 1 L homeolog antibody, HES1 antibody, Hes1 antibody, HES4 antibody, hes1.S antibody, hes1.L antibody

Background: The Notch signaling pathway is important for cell-cell communication, which involve gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. It critically influences cell proliferation, differentiation, and apoptosis in metazoans. The hairy and enhancer of split (HES) family is a basic helix-loop-helix (bHLH) type trancriptional repressor and acts as Notch effectors by negatively regulating expression of downstream target genes such as tissue-specific transcription factors. HES-1 is an upstream negative regulator of REST expression. Silencing of the transcriptional repressor REST is required for terminal differentiation of neuronal and beta-cells. Recent integrative genomic analyses on HES/HEY family suggest that HES1 and HES3 are target genes of the embryonic stem cell-specific network of transcription factors, and that HES1, HES5, HEY1, HEY2 and HEYL are target genes of Notch signaling pathway.

Pathways: DNA Damage Repair