SIRT2 antibody

Catalog No. ABIN5610565

Product Details anti-SIRT2 Antibody

Target: SIRT2 (Sirtuin 2 (SIRT2))

Reactivity: Human, Rat, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIRT2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: Mouse monoclonal to SirT2.

Specificity: This antibody detects endogenous levels of SirT2 and does not cross-react with related proteins.

Characteristics: Mouse Monoclonal to SirT2.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Purified recombinant human SirT2 protein expressed in E.coli.

Clone: 1D4-H11-H11

Isotype: IgG2b

Application Details

Application Notes: WB 1:500-2000
ELISA 1:10000-20000

Comment:

Isoform 1 is expressed in heart, liver and skeletal muscle, weakly expressed in the cortex. Isoform 2 is strongly expressed in the cortex, weakly expressed in heart and liver. Weakly expressed in several malignancies including breast, liver, brain, kidney and prostate cancers compared to normal tissues. Weakly expressed in glioma cell lines compared to normal brain tissues (at protein level). Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for SIRT2

Target: SIRT2 (Sirtuin 2 (SIRT2))

Alternative Name: SirT2 (SIRT2 Products)

Synonyms: CG5085 antibody, D.mel2 antibody, Dmel\\CG5085 antibody, SIRT2 antibody, dSIRT2 antibody, sir2 antibody, Sirt2 antibody, BmSirt2 antibody, AtSRT2 antibody, SIRTUIN 2 antibody, T2K12.8 antibody, sirtuin 2 antibody, SIR2 antibody, SIR2L antibody, SIR2L2 antibody, 5730427M03Rik antibody, Sir2l antibody, wu:fb57d05 antibody, zgc:55966 antibody, zgc:77003 antibody, Sirtuin 2 antibody, sirtuin 2 antibody, sirtuin 2 S homeolog antibody, NAD-dependent deacetylase sirtuin 2 homolog antibody, sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) antibody, Sirt2 antibody, SIRT2 antibody, sirt2.S antibody, SRT2 antibody, sirt2 antibody

Molecular Weight: 43kDa

Gene ID: 22933

UniProt: Q8IXJ6