×
For best experience we recommend to activate Javascript in your browser.
FZR1 antibody (AA 1-496)
FZR1
Reactivity: Human
WB
Host: Mouse
Monoclonal
1621CT637-76-67
unconjugated
Product Details anti-FZR1 Antibody
(hide)
Target
See all FZR1 Antibodies
FZR1
(Fizzy/cell Division Cycle 20 Related 1 (FZR1))
Binding Specificity
All epitopes for FZR1 antibodies
AA 1-496
Reactivity
All reactivities for FZR1 antibodies
Human
Host
All hosts for FZR1 antibodies
Mouse
Clonality
All clonalities for FZR1 antibodies
Monoclonal
Conjugate
All conjugates for FZR1 antibodies
This FZR1 antibody is un-conjugated
Application
All applications for FZR1 antibodies
Western Blotting (WB)
Purification
Purified
Immunogen
Human recombinant protein corresponding to amino acids 1-496 was used as the immunogen for this FZR1 antibody.
Clone
1621CT637-76-67
Isotype
IgG1 kappa
Top Product
Discover our top product FZR1 Primary Antibody
Alternatives
(show)
Application Details
(hide)
Application Notes
Western blot: 1:1000-2000
Restrictions
For Research Use only
Handling
(hide)
Buffer
In 1X PBS, pH 7.4, with 0.09 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot the FZR1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target Details for FZR1
(hide)
Target
FZR1
(Fizzy/cell Division Cycle 20 Related 1 (FZR1))
Alternative Name
FZR1 / Fizzy related protein 1 (FZR1 Products )
Synonyms
CDH1-C antibody, FYR antibody, FZR antibody, CDH1 antibody, fzr1 antibody, CDC20C antibody, FZR2 antibody, HCDH antibody, HCDH1 antibody, AW108046 antibody, Cdh1 antibody, Fyr antibody, zgc:55450 antibody, fizzy and cell division cycle 20 related 1 antibody, fizzy/cell division cycle 20 related 1 antibody, fizzy-related protein homolog antibody, fizzy/cell division cycle 20 related 1 (Drosophila) antibody, fizzy/cell division cycle 20 related 1a antibody, Fzr1 antibody, CDH1-C antibody, FZR1 antibody, LOC100027495 antibody, LOC100179951 antibody, fzr1a antibody
Background
Fizzy related protein 1 is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Gene ID
51343
UniProt
Q9UM11
Pathways
DNA Replication , Synthesis of DNA
Recently viewed
(hide)