ADAMTS4 antibody (AA 813-837)

Catalog No. ABIN5647323

Product Details anti-ADAMTS4 Antibody

Target: ADAMTS4 (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4))

Binding Specificity: AA 813-837

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAMTS4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity purified

Immunogen: Amino acids 813-837 (TPQDWLHRRAQILEILRRRPWAGRK) from the human protein were used as the immunogen for the ADAMTS4 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ADAMTS4 antibody should be determined by the researcher.\. WB: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL,ELISA: 0.1-0.5 μg/mL (human protein tested, request BSA-free format for coating)

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the ADAMTS4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for ADAMTS4

Target: ADAMTS4 (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4))

Alternative Name: ADAMTS4 (ADAMTS4 Products)

Synonyms: 3830423K05 antibody, ADAM-TS4 antibody, ADAMTS-2 antibody, ADMP-1 antibody, mKIAA0688 antibody, ADAMTS-4 antibody, ADAMTS4 antibody, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 antibody, ADAM metallopeptidase with thrombospondin type 1 motif 4 antibody, ADAM metallopeptidase with thrombospondin type 1 motif, 4 antibody, Adamts4 antibody, ADAMTS4 antibody

Background: ADAMTS4, A disintegrin and metalloproteinase with thrombospondin motifs 4, is an enzyme that in humans is encoded by the ADAMTS4 gene. ADAMTS4 is a member of the large ADAMTS family of zinc-dependent proteases. The human ADAMTS4 gene is mapped to chromosome 1 by somatic cell hybrid analysis. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

UniProt: O75173