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AIMP2 antibody (AA 150-200)
AIMP2
Reactivity: Human
WB, ELISA, IHC (p), IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-AIMP2 Antibody
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Target
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AIMP2
(Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2 (AIMP2))
Binding Specificity
All epitopes for AIMP2 antibodies
AA 150-200
Reactivity
All reactivities for AIMP2 antibodies
Human
Host
All hosts for AIMP2 antibodies
Rabbit
Clonality
All clonalities for AIMP2 antibodies
Polyclonal
Conjugate
All conjugates for AIMP2 antibodies
This AIMP2 antibody is un-conjugated
Application
All applications for AIMP2 antibodies
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
Specificity
AIMP2 antibody is human specific. AIMP2 antibody is predicted to not cross-react with AIMP1.
Purification
AIMP2 antibody is affinity chromatography purified via peptide column.
Immunogen
AIMP2 antibody was raised against a 16 amino acid peptide near the center of human AIMP2. The immunogen is located within amino acids 150 - 200 of AIMP2.
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
AIMP2 antibody can be used for detection of AIMP2 by Western blot at 1 - 2 μ,g/mL.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
AIMP2 antibody is supplied in PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
AIMP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Target Details for AIMP2
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Target
AIMP2
(Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2 (AIMP2))
Alternative Name
AIMP2 (AIMP2 Products )
Synonyms
jtv1 antibody, MGC53242 antibody, pro0992 antibody, JTV1 antibody, JTV-1 antibody, P38 antibody, AA407136 antibody, AA407225 antibody, Aimp2(p38) antibody, Jtv1 antibody, aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 L homeolog antibody, aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 antibody, aminoacyl tRNA synthetase complex interacting multifunctional protein 2 antibody, aimp2.L antibody, aimp2 antibody, AIMP2 antibody, Aimp2 antibody
Background
AIMP2 was initially identified as a part of an aminoacyl-tRNA synthesase complex (1). It was later discovered to be a cofactor and substrate of Parkin, a Ring-type E3 ubiquitin ligase that is important for the survival of dopamine neurons in Parkinson's disease, accumulation of AIMP2 in these cells lead to catecholaminergic cell death (2). AIMP2 can also bind to TRAF2, a key player in the TNF-alpha signaling pathway, causing the ubiquitination of TRAF2 by cIAP1, leading to TNF-alpha-dependent apoptosis (3). Finally, AIMP2 has been suggested to function as a tumor suppressor (4).
Molecular Weight
Predicted: 35 kDa Observed: 36 kDa
Gene ID
7965
NCBI Accession
NP_006294
UniProt
Q13155
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