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Cortactin antibody (AA 464-468)
CTTN
Reactivity: Human, Mouse, Rat
WB, IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Cortactin Antibody
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Target
See all Cortactin (CTTN) Antibodies
Cortactin (CTTN)
Binding Specificity
All epitopes for Cortactin antibodies
AA 464-468
Reactivity
All reactivities for Cortactin antibodies
Human, Mouse, Rat
Host
All hosts for Cortactin antibodies
Rabbit
Clonality
All clonalities for Cortactin antibodies
Polyclonal
Conjugate
All conjugates for Cortactin antibodies
This Cortactin antibody is un-conjugated
Application
All applications for Cortactin antibodies
Western Blotting (WB), Immunohistochemistry (IHC)
Specificity
This antibody detects endogenous level of total Cortactin protein.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
Cortactin (Ab-466) antibody was raised against a peptide sequence around aa.464~468 (P-V-Y-E-T) derived from Human CORTACTIN.
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Alternatives
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Application Details
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Application Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store antibody at -20°C for up to one year.
Target Details for Cortactin
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Target
Cortactin (CTTN)
Alternative Name
Cortactin (CTTN Products )
Synonyms
EMS1 antibody, 1110020L01Rik antibody, Ems1 antibody, Cttnb antibody, CG3637 antibody, Dmel\CG3637 antibody, cortactin antibody, cttn antibody, CTTN1 antibody, P85.25 antibody, Cttn antibody, ems1 antibody, CTTN antibody, cortactin antibody, CG3637 gene product from transcript CG3637-RD antibody, cortactin S homeolog antibody, cortactin L homeolog antibody, src substrate cortactin antibody, Src substrate cortactin antibody, CTTN antibody, Cttn antibody, Cortactin antibody, cttn.S antibody, cttn.L antibody, cttn antibody, CpipJ_CPIJ006351 antibody, Bm1_57220 antibody, LOC100533277 antibody
Background
Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.
Molecular Weight
85 kDa
Gene ID
2017
NCBI Accession
NP_005222
UniProt
Q14247
Pathways
MAPK Signaling
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