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PRKAA1 antibody (AA 485-489)
PRKAA1
Reactivity: Human, Mouse, Rat
WB, IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-PRKAA1 Antibody
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Target
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PRKAA1
(Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1))
Binding Specificity
All epitopes for PRKAA1 antibodies
AA 485-489
Reactivity
All reactivities for PRKAA1 antibodies
Human, Mouse, Rat
Host
All hosts for PRKAA1 antibodies
Rabbit
Clonality
All clonalities for PRKAA1 antibodies
Polyclonal
Conjugate
All conjugates for PRKAA1 antibodies
This PRKAA1 antibody is un-conjugated
Application
All applications for PRKAA1 antibodies
Western Blotting (WB), Immunohistochemistry (IHC)
Specificity
This antibody detects endogenous level of total AMPKα,1 protein.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
AMPKa1 (Ab-487) antibody was raised in was raised against a peptide sequence around aa.485~489 (S-G-S-V-S) derived from Human AMPKα,1.
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Application Details
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Application Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store antibody at -20°C for up to one year.
Target Details for PRKAA1
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Target
PRKAA1
(Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1))
Alternative Name
AMPKa1 (PRKAA1 Products )
Synonyms
AMPK antibody, AMPKa1 antibody, cb116 antibody, im:7154392 antibody, sb:cb130 antibody, wu:fa94c10 antibody, AMPK1 antibody, AMPKalpha1 antibody, AI194361 antibody, AI450832 antibody, AL024255 antibody, C130083N04Rik antibody, ampk antibody, ampka1 antibody, PRKAA1 antibody, protein kinase AMP-activated catalytic subunit alpha 1 antibody, protein kinase, AMP-activated, alpha 1 catalytic subunit antibody, protein kinase, AMP-activated, alpha 1 catalytic subunit L homeolog antibody, PRKAA1 antibody, prkaa1 antibody, Prkaa1 antibody, prkaa1.L antibody
Background
Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.
Molecular Weight
63 kDa
Gene ID
5562
NCBI Accession
NP_006242
UniProt
Q13131 , P54646
Pathways
AMPK Signaling , Carbohydrate Homeostasis , Regulation of Carbohydrate Metabolic Process , Warburg Effect
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