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CHEK2 antibody (AA 514-518)
CHEK2
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-CHEK2 Antibody
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Target
See all CHEK2 Antibodies
CHEK2
(Checkpoint Kinase 2 (CHEK2))
Binding Specificity
All epitopes for CHEK2 antibodies
AA 514-518
Reactivity
All reactivities for CHEK2 antibodies
Human
Host
All hosts for CHEK2 antibodies
Rabbit
Clonality
All clonalities for CHEK2 antibodies
Polyclonal
Conjugate
All conjugates for CHEK2 antibodies
This CHEK2 antibody is un-conjugated
Application
All applications for CHEK2 antibodies
Western Blotting (WB)
Specificity
This antibody detects endogenous levels of total Chk2 protein.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
Chk2 (Ab-516) antibody was raised against a peptide sequence around aa. 514~518 (Q-P-S-T-S) derived from Chk2.
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Alternatives
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Application Details
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Application Notes
Western Blot: 1:500~1:1000
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store antibody at -20°C for up to one year.
Target Details for CHEK2
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Target
CHEK2
(Checkpoint Kinase 2 (CHEK2))
Alternative Name
Chk2 (CHEK2 Products )
Synonyms
CDS1 antibody, CHK2 antibody, HuCds1 antibody, LFS2 antibody, PP1425 antibody, RAD53 antibody, hCds1 antibody, fa66f08 antibody, wu:fa66f08 antibody, zgc:55865 antibody, Cds1 antibody, HUCDS1 antibody, Rad53 antibody, Chk2 antibody, cds1 antibody, chek2 antibody, chk2 antibody, hucds1 antibody, lfs2 antibody, pp1425 antibody, rad53 antibody, checkpoint kinase 2 antibody, serine/threonine-protein kinase chk2 antibody, checkpoint kinase 2 L homeolog antibody, CHEK2 antibody, chek2 antibody, Chek2 antibody, MCYG_07308 antibody, chek2.L antibody
Background
The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation
Molecular Weight
62 kDa
Gene ID
11200
NCBI Accession
NP_001005735
UniProt
O96017
Pathways
p53 Signaling , Apoptosis , Cell Division Cycle
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