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ME1 antibody (N-Term)
ME1
Reactivity: Human, Mouse, Rat
WB, ELISA, IHC (p)
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-ME1 Antibody
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Target
See all ME1 Antibodies
ME1
(Malic Enzyme 1, NADP(+)-Dependent, Cytosolic (ME1))
Binding Specificity
All epitopes for ME1 antibodies
N-Term
Reactivity
All reactivities for ME1 antibodies
Human, Mouse, Rat
Host
All hosts for ME1 antibodies
Rabbit
Clonality
All clonalities for ME1 antibodies
Polyclonal
Conjugate
All conjugates for ME1 antibodies
This ME1 antibody is un-conjugated
Application
All applications for ME1 antibodies
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
ME1 antibody is human, mouse and rat reactive. ME1 antibody is predicted not to cross-react with ME2.
Purification
ME1 antibody is affinity chromatography purified via peptide column.
Immunogen
ME1 antibody was raised against a 16 amino acid peptide near the amino terminus of human ME1. The immunogen is located within the first 50 amino acids of ME1.
Isotype
IgG
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Alternatives
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anti-Malic Enzyme 1, NADP(+)-Dependent, Cytosolic (ME1) (N-Term) antibody
ME1
Reactivity: Human, Mouse, Rat, Rabbit, Dog, Cow, Sheep, Horse, Pig
WB, IHC
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
ME1 antibody can be used for detection of ME1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
ME1 Antibody is supplied in PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
ME1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Target Details for ME1
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Target
ME1
(Malic Enzyme 1, NADP(+)-Dependent, Cytosolic (ME1))
Alternative Name
ME1 (ME1 Products )
Synonyms
HUMNDME antibody, MES antibody, D9Ertd267e antibody, Mdh-1 antibody, Mod-1 antibody, Mod1 antibody, MOD1 antibody, ME1 antibody, zgc:153079 antibody, malic enzyme 1 antibody, malic enzyme 1, NADP(+)-dependent, cytosolic antibody, ME1 antibody, Me1 antibody, me1 antibody
Background
ME1, also known as NADP-ME, MES or HUMNDME, may play an important role as a housekeeping protein within the cell (1). ME1 is a 572 amino acid cytoplasmic protein that belongs to the malic enzyme family (2). It is expressed ubiquitously with highest expression in liver and white adipose tissue. ME1 functions as an NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis (3). The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles (3,4). ME1 is regulated by both thyroid hormone levels and the amount of carbohydrates in the diet (5).
Molecular Weight
Predicted: 63 kDa Observed: 63 kDa
Gene ID
4199
NCBI Accession
NP_002386
UniProt
P48163
Pathways
Regulation of Lipid Metabolism by PPARalpha
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