MAPK13 antibody

Catalog No. ABIN5696832

Product Details anti-MAPK13 Antibody

Target: MAPK13 (Mitogen-Activated Protein Kinase 13 (MAPK13))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This MAPK13 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Immunogen: mitogen-activated protein kinase 13

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for MAPK13

Target: MAPK13 (Mitogen-Activated Protein Kinase 13 (MAPK13))

Alternative Name: MAPK13 (MAPK13 Products)

Synonyms: F24B9.3 antibody, F24B9_3 antibody, MAPK 13 antibody, MAPK-13 antibody, PRKM13 antibody, SAPK4 antibody, p38delta antibody, Serk4 antibody, Prkm13 antibody, sapk4 antibody, prkm13 antibody, Protein kinase superfamily protein antibody, mitogen-activated protein kinase 13 antibody, mitogen activated protein kinase 13 antibody, ATMPK13 antibody, MAPK13 antibody, Mapk13 antibody, mapk13 antibody

Background: Synonyms:PRKM13, SAPK4 Background:Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.

Molecular Weight: 42 kDa

Gene ID: 5603

UniProt: O15264

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Hepatitis C, BCR Signaling, S100 Proteins