Prosaposin antibody

Catalog No. ABIN5698177

Product Details anti-Prosaposin Antibody

Target: Prosaposin (PSAP)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Prosaposin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Immunogen: prosaposin

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

HepG2 cells were subjected to SDS PAGE followed by western blot with FNab06840( PSAP Antibody) at dilution of 1:600

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for Prosaposin

Target: Prosaposin (PSAP)

Alternative Name: PSAP (PSAP Products)

Synonyms: GLBA antibody, SAP1 antibody, AI037048 antibody, SGP-1 antibody, SGP1A antibody, cb759 antibody, wu:fa14a06 antibody, wu:fb36e02 antibody, wu:fb58g07 antibody, PSAP antibody, PSP-A antibody, SFTPA1B antibody, SP-A antibody, prosaposin antibody, surfactant protein A1 antibody, PSAP antibody, Psap antibody, psap antibody, LOC100011417 antibody, LOC100304726 antibody, LOC100526719 antibody, SFTPA1 antibody

Background: Synonyms:GLBA, SAP1 Background:This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Gene ID: 5660

UniProt: P07602

Pathways: Positive Regulation of Endopeptidase Activity