Prosaposin antibody
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- Target See all Prosaposin (PSAP) Antibodies
- Prosaposin (PSAP)
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Prosaposin antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Immunogen
- prosaposin
- Isotype
- IgG
- Top Product
- Discover our top product PSAP Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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HepG2 cells were subjected to SDS PAGE followed by western blot with FNab06841( PSAP Antibody) at dilution of 1:600
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- Prosaposin (PSAP)
- Alternative Name
- PSAP (PSAP Products)
- Synonyms
- GLBA antibody, SAP1 antibody, AI037048 antibody, SGP-1 antibody, SGP1A antibody, cb759 antibody, wu:fa14a06 antibody, wu:fb36e02 antibody, wu:fb58g07 antibody, PSAP antibody, PSP-A antibody, SFTPA1B antibody, SP-A antibody, prosaposin antibody, surfactant protein A1 antibody, PSAP antibody, Psap antibody, psap antibody, LOC100011417 antibody, LOC100304726 antibody, LOC100526719 antibody, SFTPA1 antibody
- Background
- Synonyms:GLBA, SAP1 Background:Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase(EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase(EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A(EC 3.1.6.8), GM1 gangliosides by beta-galactosidase(EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A(EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator(EC 3.1.4.12). Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
- Gene ID
- 5660
- UniProt
- P07602
- Pathways
- Positive Regulation of Endopeptidase Activity
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