EXOSC5 antibody
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- Target See all EXOSC5 Antibodies
- EXOSC5 (Exosome Component 5 (EXOSC5))
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Reactivity
- Human, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This EXOSC5 antibody is un-conjugated
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Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
- Immunogen
- exosome component 5
- Isotype
- IgG
- Top Product
- Discover our top product EXOSC5 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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K-562 cells were subjected to SDS PAGE followed by western blot with FNab02905(EXOSC5 antibody) at dilution of 1:500
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- EXOSC5 (Exosome Component 5 (EXOSC5))
- Alternative Name
- EXOSC5 (EXOSC5 Products)
- Synonyms
- si:ch211-194n6.2 antibody, zgc:153707 antibody, EXOSC5 antibody, RRP41B antibody, RRP46 antibody, Rrp46p antibody, hRrp46p antibody, p12B antibody, D7Wsu180e antibody, exosome component 5 antibody, exosc5 antibody, EXOSC5 antibody, Exosc5 antibody
- Background
- Synonyms:CML28, RRP46 Background:Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits(Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
- Molecular Weight
- 28-30 kDa
- Gene ID
- 56915
- UniProt
- Q9NQT4
- Pathways
- SARS-CoV-2 Protein Interactome
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