TRIB3 antibody
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- Target See all TRIB3 Antibodies
- TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TRIB3 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunoprecipitation (IP)
- Immunogen
- tribbles homolog 3 (Drosophila)
- Isotype
- IgG
- Top Product
- Discover our top product TRIB3 Primary Antibody
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- Application Notes
- WB:1:500-1:5000,IP:1:200-1:2000
- Comment
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mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab08966(TRIB3 antibody) at dilution of 1:600
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))
- Alternative Name
- TRIB3 (TRIB3 Products)
- Synonyms
- zgc:76966 antibody, TRIB3 antibody, C20orf97 antibody, NIPK antibody, SINK antibody, SKIP3 antibody, TRB3 antibody, Ifld2 antibody, Nipk antibody, TRB-3 antibody, Trb3 antibody, tribbles pseudokinase 3 antibody, trib3 antibody, TRIB3 antibody, Trib3 antibody
- Background
- Synonyms:C20orf97, NIPK, SINK, SKIP3, TRB 3, TRB3, TRIB3, Tribbles homolog 3 Background:Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.
- Molecular Weight
- 42kDa
- Gene ID
- 57761
- UniProt
- Q96RU7
- Pathways
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
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