MARK2 antibody
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- Target See all MARK2 Antibodies
- MARK2 (MAP/microtubule Affinity-Regulating Kinase 2 (MARK2))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MARK2 antibody is un-conjugated
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Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
- Immunogen
- MAP/microtubule affinity-regulating kinase 2
- Isotype
- IgG
- Top Product
- Discover our top product MARK2 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab05013(MARK2 antibody) at dilution of 1:1000
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- MARK2 (MAP/microtubule Affinity-Regulating Kinase 2 (MARK2))
- Alternative Name
- MARK2 (MARK2 Products)
- Synonyms
- EMK-1 antibody, EMK1 antibody, PAR-1 antibody, Par-1b antibody, Par1b antibody, AU024026 antibody, Emk antibody, Par-1 antibody, mKIAA4207 antibody, microtubule affinity regulating kinase 2 antibody, MAP/microtubule affinity regulating kinase 2 antibody, MARK2 antibody, Mark2 antibody
- Background
- Synonyms:EMK1 Background:Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins(DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.
- Molecular Weight
- 78 kDa,80 kDa
- Gene ID
- 2011
- UniProt
- Q7KZI7
- Pathways
- SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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